FREQUENCY OF HER-2/NEU POSITIVITY IN CARCINOMA BREAST PATIENTS IN TERTIARY CARE HOSPITALS OF BALOCHISTAN

Shahzada Amir Ahmed Babar, Saira Batool, Tahir Aslam, Khurshid Ahmed Baloch

Abstract


 

 

Objective: To examine the frequency of HER-2/neu positivity in carcinoma breast patients in tertiary care hospitals of Balochistan.

Methodology: This multi-center study was conducted in the Department of Surgery, Bolan Medical Complex Hospital and Sandeman Provincial Hospital, Quetta-Balochistan, from January 01, 2015 to June 30, 2015. All female patients undergoing surgery for carcinoma (Ca) breast with age 25 to 65 years, duration more than 6 months, size of tumor 2 cm and above and Ca breast grade 1-3 were included. Breast tissue was sent for histopathology and HER-2/ neu immunostain (neu) by immunohistochemistry.

Results: Mean age of the patients was 57.06 ±8.91 years and mean BMI 25.04 ±5.51 Kg/m2. Most of the patients (n=76, 92.7%) were married, smoking status was found in 4 (4.9%), pre-menopausal status in 13 (15.9%), oral contraceptive use in 11 (13.4%), family history of breast carcinoma in 22 (26.8%), lactation in 18 (22%) and multi-parity in 55 (67.1%). HER-2/neu was found to be positive in 19 (23.2%) patients.

Conclusion: Higher frequency of HER-2/neu positivity was found in carcinoma breast patients in tertiary care hospitals of Balochistan.


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