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Objective: To assess the prophylactic use of misoprostol in management ofthird stage of labour and prevention of atonic uterus, and comparing it withconventional i/v syntocinon use in third stage of labour.Methodology: This quasi experimental study was conducted at departmentof obstetrics and gynecology unit A, Mardan Medical Complex Hospital Mardan,from May 2011 to May 2012. Two hundreds labouring females wereincluded in the study and divided into 2 groups, a control group (100 womenwho received 5 units syntocinon) and a study group (100 women who received800ug rectal misoprostol) immediately after delivery of the baby. Duration ofthird stage of labour, blood loss after delivery were recorded and comparedbetween the two groups. Side effects of both drugs were also noted.Results: There was not any significant difference in blood loss and durationof third stage of labour in both groups. The frequency of atonic PPH (postpartumhemorrhage) in study and control groups was also similar.Conclusion: Misoprostol can be used for the management of third stage oflabour and it can reduce atonic PPH. It efficacy and safety is similar to that ofsyntocinone.
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