COMPARATIVE STUDY OF CO-INDUCTION WITH THIOPENTONE AND MIDAZOLAM VERSUS THlOPENTONE ALONE IN HYPERTENSIVE PATIENTS

Abstract

Objective: To compare the variations of heart rate and diastolic blood pressure in hypertensive patients

in co-induction of anesthesia with thiopentone & midazolam versus thiopentone alone.

Material and Methods: This comparative study was conducted in Anesthesia Department Khyber

Teaching Hospital, Peshawar from April, 2006 to September, 2006. Hundred indoor hypertensive cases of

surgical units were included in the study. They were equally divided into two groups of 50 patients each.

Group A: 50 cases who were anesthetized with thiopentone sodium alone. Group B: 50 cases who were

anesthetized with midazolam/thiopentone sodium combination.

Results: A total of 100 cases were studied. In 50 cases of group A (induction with thiopentone alone), the

heart rate remained stable in 36% (n=18) cases and the diastolic blood pressure remained stable in 34%

(n=17) cases.While in group B (co-induction with thiopentone / midazolam), heart rate remained stable in

72% (n=36) cases and diastolic blood pressure in 70% (n=35) cases. Patients with unstable heart rate and

diastolic blood pressure were more in group A (thiopentone induction group) while patients with stable

heart rate and diastolic blood pressure were more in group B (co-induction group).

Conclusion: Co-induction with thiopentone and midazolam provides better hemodynamic stability as

compared to induction with thiopentone alone in hypertensive patients. However large scale randomised

controled trials are needed to study the haemodynamic stability of thiopentone and midazolam.