EVALUUATION OF ERECTILE DYSFUNCTION AND RETROGRADE EJACULATION IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA RECEIVING COMBINED DRUG THERAPY

Abstract

Objective: To determine the frequency of erectile dysfunction and retrograde ejaculation in patients with benign prostatic hyperplasia (BPH) receiving combined pharmacotherapy with dutasteride and tamsulosin
Methodology: This cross sectional study was conducted on 205 patients enrolled from outpatient department (OPD) of Institute of Kidney Diseases (IKD) Peshawar from September 2017 to March 2018. The International Prostate Symptom Scores (IPSS) score and ultrasound were used to select patients of BPH suitable for medical management rather than surgery. The International Index Erectile Function scoring (IIEFS) was used to measure erectile dysfunction, prior to and after treatment with dutasteride and tamsulosin. Retrograde ejaculation was recorded from history after two months follow-up.
Results: The mean age was 60 years with SD ± 2.16. IIEF score for all patients was ≥ 25, which reflected normal erectile function prior to treatment. But after 2 months of follow up 17% patients had IIEF score < 11 (severe dysfunction) and 83% patients had IIEF score ≥ 22 (mild to moderate dysfunction). Thirty seven (37%) patients had retrograde ejaculation.
Conclusion: Retrograde ejaculation and erectile dysfunction are important adverse effects of combined drug regimen for the treatment of symptoms of benign prostatic hyperplasia.