Initial Experience with I131 MIBG Imaging In Patients With Neuroblastoma

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H. A. Khan
A. Saeed Shah
Sher Muhammad Khan
Iftikhar Ahmad
G.M. Shah Syed

Abstract

Metaiodobenzyl quanidine was synthesized from metaiodobenzyl amine hydrochloride and cyanamide at different temperatures. The yield was found to be 60-70%. The product was characterized by UV, IR, and NMR spectroscopic techniques. The characterized product was labelled with iodine -131 and labeling efficiency was determined by radio-TLC technique. Labeling yield up to 95% was achieved. Five patient with biopsy proven neuroblastoma were imaged. In two patients intrabdominal primary tumor was successfully localized and a thoracic metastatic site was detected in one of them. MIBG scanning was normal in remaining three patients.

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1.
Khan HA, Shah AS, Khan SM, Ahmad I, Syed GS. Initial Experience with I131 MIBG Imaging In Patients With Neuroblastoma. J Postgrad Med Inst [Internet]. 2011 Aug. 25 [cited 2024 Mar. 28];7(2). Available from: https://www.jpmi.org.pk/index.php/jpmi/article/view/435
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