TY - JOUR AU - Misbah Manzoor, AU - Babar, Bakht PY - 2023/03/01 Y2 - 2024/03/29 TI - LEFT VENTRICULAR DIASTOLIC DYSFUNCTION AND ITS PATTERN IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT MICROALBUMINURIA JF - Journal of Postgraduate Medical Institute JA - J Postgrad Med Inst VL - 37 IS - 1 SE - Original Article DO - 10.54079/jpmi.37.1.3074 UR - https://www.jpmi.org.pk/index.php/jpmi/article/view/3074 SP - 36-40 AB - <p><strong>Objective:</strong> To find out and compare left ventricular diastolic dysfunction and its pattern among patients with type-2 diabetes mellitus (T2DM) with and without micro-albuminuria.</p><p><strong>Methodology:</strong> This comparative cross section study was conducted in the outpatient department of Peshawar Institute of Cardiology from August 2021 to January 2022. A total of 228 T2DM normotensive patients, aged 30 to 65 years were enrolled and divided into two groups. Group-A contained 114 T2DM with no-albuminuria and Group-B had 114 T2DM micro-albuminuria patients. Socio-demographic, anthropometric, laboratory character­istics and echocardiographic parameters of all patients were noted. Qualitative variables were analyzed using chi-square test while quantitative variables were analyzed using t-test. P value &lt;0.05 was considered statistically significant.</p><p><strong>Results:</strong> Out of a total of 228 patients, 122 (53.5%) were male. Overall, mean age was noted to be 49.18+8.8 years. In comparison to group-A, duration of diabetes was significantly more among patients of group-B (p&lt;0.001). Renal functions were significantly preserved in Group-A in comparison to Group-B (p=0.003) as shown by eGFR. Left ventricular diastolic dysfunction was found to be 49.1% among patients of Group-A in comparison to 71.1% in Group-B and pattern of left ventricular diastolic dysfunction showed a significant difference between patients of both study groups (0.004).</p><p><strong>Conclusion:</strong> Left ventricular diastolic dysfunction was significantly high among T2DM patients with micro-albu­minuria. Significant associations were found in terms altered left ventricular diastolic echocardiographic features among T2DM patients with micro-albuminuria.</p> ER -