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Material and Methods:
In neurosurgical patients undergoing craniotomy, infiltration of the scalp with solution
containing adrenaline alone causes significant hypertension. The addition of lignocaine attenuates the
hypertensive response but causes decrease in blood pressure.
Episodes of tachycardia occurred more frequently in group B. Systolic blood pressure, diastolic
blood pressure and mean arterial pressure were significantly increased in group B. Significant decrease in
diastolic blood pressure and mean arterial pressure occurred in group A.
This comparative study was carried out at AIMS international hospital Hayatabad,
Peshawar from January to June 2009. Cardiovascular response to scalp infiltration with adrenaline was
noted in 100 unpremedicated patients undergoing craniotomy. They were divided into 2 groups of 50
patients each. Group A received lignocaine 2% with adrenaline 1:200,000 and Group B received normal
saline with adrenaline 1:200,000.
To find out changes in the heart rate, systolic blood pressure, diastolic blood pressure and mean
arterial pressure after infiltrating scalp with adrenaline with or without Lignocaine in craniotomies.
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