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Objective: To determine the levels and ratios of serum LH, FSH and Testosterone, among men having
history of infertility.
Material and Methods: A non-interventional descriptive study was carried out in the Department of
Public Health Laboratories Division, NIH, Islamabad from January 2004 to December 2005. Two hundred
fifty infertile men, classified as azoospermic (50), oligozoospermic (75), asthenozoospermic (50) and
normozoospermic (75) were studied for serum LH, FSH and Testosterone, in addition to 50 proven fathers.
Results: The respective FSH (mIU/ml), LH (mIU/ml) and Testosterone (nmol/L) levels for the groups were
22.924.15, 13.852.33 and 11.860.70 (Azoospermia), 16.823.79, 10.921.22 and 11.88+1.06
(Oligozoospermia), 3.220.61, 3.921.17 and 16.24+2.05 (Asthenozoospermia) while in normozoospermic
men were 5.530.52, 7.400.60 and 17.29+1.02, The proven fathers group had 7.74+0.71 mIU/ml LH,
6.75+1.06 mIU/ml FSH and 15.88+1.15 nmol/ml testosterone, respectively.
The LH/FSH and FSH/LH ratios were 0.77+0.08 and 1.84+0.22 (Azoospermia), 1.78+0.41 and 1.47+0.18
(Oligozoospermia), 1.51+0.46 and 1.28+0.28 (Asthenozoospermia) while in normozoospermic and proven
fathers were 1.55+0.16 and 0.85+0.10,1.67+0.22 and0.94+0.12. Similarly, the LH/T and T/LH ratios were
1.17+0.28 and 0.86+2.70 (Azoospermia), 0.92+0.28 and 1.08+0.17 (Oligozoospermia), 0.30+0.10 and
4.14+10.4 (Asthenozoospermia) and in normozoospermic were 0.42+0.08 and 2.34+0.48.The ratios
observed for T/FSH and FSH/T were 0.52+0.17 and 1.93+5.95 (Azoospermia), 0.71+0.28 and 1.42+3.57
(Oligozoospermia), 5.04+3.38 and 0.20+0.30 (Asthenozoospermia) and in normozoospermic men were
2.82+0.90 and 0.35+1.12, while in proven fathers were 4.09+0.57and 1.04+0.53 respectively.
Conclusion: Altered/disturbed concentrations of gonadotropins and androgenic hormones and their ratios
cause infertility, since all these hormones act synergistically.
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