A COMPARATIVE ANALYSIS OF IN-HOSPITAL LEFT VENTRICULAR FUNCTION IN PATIENTS WITH SUCCESSFUL OR UNSUCCESSFUL STREPTOKINASE THROMBOLYSIS FOLLOWING ACUTE MYOCARDIAL INFARCTION
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Objective: To compare in-hospital left ventricular function in patients with unsuccessful and successfulthrombolysis presenting with acute myocardial infarction treated with streptokinase.
Methodology: This comparative study was conducted at department of Cardiology, Lady Reading HospitalPeshawar, from October 2006 to October 2007. Two hundred patients with first acute myocardial infarctionwere divided into two groups: group A (successful thrombolysis) and group B (unsuccessful thrombolysis),using ECG criteria. To determine Left Ventricular Function, 2-D Echo was used.
Results: Group A included 136 (68%) patients and group B included 64 (32%) patients. Impaired leftventricular function was found in 41 (30.1%) patients in group A and 41 (64.1%) patients in group B (p<0.001). Left ventricular failure was present in 31 (22.8%) patients of group A and 30 (46.9%) patients ofgroup B (p=0.001). Cardiogenic shock was diagnosed in 2 (1.5%) patients in group A and 6 (9.4%)patients in group B (p=0.008).
Conclusion: Presence of LVF is strongly associated with unsuccessful thrombolytic therapy in this groupof patients.
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