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Hikmatullah Qureshi
Amir Amanullah
Khalid Mahmood Khan
Farah Deeba


Objective: To determine the sensitivity and specificity of fine needle aspiration cytology (FNAC), by

comparing the results with excision biopsy.

Material and Methods: This observational and comparative study was conducted in Surgical B Ward of

Khyber teaching hospital Peshawar, Pakistan from August 2002 to May 2003. A total of 50 women, who

had a clinically palpable breast lump were subjected to concurrent FNAC and excision biopsy.

Results: Out of 12 malignant lesions on excision biopsy, FNAC correctly diagnosed 9, and 2 were

diagnosed suspicious, and the remaining one was misdiagnosed as non malignant. So false negative being

1/12 (8.3%). Of 38 benign cases on excision biopsy, FNAC diagnosed correctly duct ectasia 3, tuberculosis

2, and galactocele 1, while out of 22 fibroadenoma, FNAC diagnosed 20, and 2 were diagnosed as

unsatisfactory. Ten cases diagnosed as fibrocystic disease on excision biopsy, FNAC picked only 6 cases

correctly. The one case diagnosed on FNAC as fibrocystic disease, turned out to be malignant on histology.

The remaining 4 cases of fibrocystic disease diagnosed on histopathology were either reported as

unsatisfactory (3 cases) or suspicious (1 case) on FNAC. The sensitivity and specificity of FNAC was

91.66% and 96.96% respectively.

Conclusion: Breast cytology was an effective and rapid method of diagnosis of breast diseases. It helps

in deciding which patient needs early open biopsy. A negative cytology does not exclude the possibility of

malignancy, as there was a false negative rate of 8.3%.

Article Details

How to Cite
Qureshi H, Amanullah A, Khan KM, Deeba F. EFFICACY OF FINE NEEDLE ASPIRATION CYTOLOGY IN THE DIAGNOSIS OF BREAST LUMPS. J Postgrad Med Inst [Internet]. 2011 Aug. 10 [cited 2023 Sep. 22];21(4). Available from: https://www.jpmi.org.pk/index.php/jpmi/article/view/184
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