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rapidity to control hypertensive emergencies of pregnancy.
Methodology: It was a comparative study, done in Gynae C unit, Lady Reading
Hospital, Peshawar. The study included hundred patients with severe gestational
hypertension â‰¥160/110 mmHg, randomly assigned to two groups
(one given intravenous hydralazine and the other oral nifedipine) to achieve a
blood pressure (BP) of â‰¤150/100 mmHg. BP was measured every 15 minutes
for one hour. Side effects were noted in terms of maternal headache and hypotension
and fetal heart rate.
Results: Both drugs controlled BP in the given time period but hydralazine
was more efficacious in terms of time and doses. The time required by hydralazine
was 41.10±20.286 minutes as compared to nifidipine was 57.90±21.855
with a significant p value of 0.000. Few doses were required to control BP in
case of hydralazine 2.74±1.35 as compared to nifidipine which was 3.86±1.45
with a significant "˜p' value of 0.000.
Conclusion: The use of either hydralazine or nifidipine controlled BP in the
target time period but hydralazine was more efficacious.
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