Main Article Content
and their association with Î²2-adrenergic receptor (Arg16Gly and Glu27Gln)
Methodology: The whole procedure for systematic review and meta-analysis
was conducted following PRISMA guidelines. The following databases Ovid,
PubMed, Wiley online library, Springer link and the Web of Knowledge were
searched for relevant articles. Random effect meta-analysis was conducted.
Heterogeneity was evaluated by I2 statistic. The funnel plots and the Eager tests
were used to assess the small study biases and potential publications.
Results: This systematic review and meta-analysis comprised a total of 9 studies.
The brief statement estimates suggested heterozygous Arg/Gly (OR =2.32;
95% CI =1.53-3.54; P value =<0.001), homozygous Gly (OR =4.78; 95% CI =2.60-
8.77, P-value =<0.001) and Gly allele (OR =1.71, 95% CI =1.14-2.56, P-value
=0.009) was significantly associated with nocturnal asthma. While Glu27Gln
polymorphism did not showed significant association with nocturnal asthma
both in genotype (OR =1.28; 95% CI =0.63-2.59; P-value =0.496) and allelic (OR
=1.65; 95% CI =0.64-4.27; P-value =0.301) analysis.
Conclusion: Heterozygous Arg/Gly, homozygous Gly/Gly and Gly Allele were
found to be significantly associated with nocturnal asthma.
Work published in JPMI is licensed under a
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.