SYSTEMATIC REVIEW AND META-ANALYSIS OF ASSOCIATION OF β2-ADRENERGIC RECEPTOR GENE POLYMORPHISMS WITH NOCTURNAL ASTHMA

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Ihsanullah Khan
Zia Ul Haq
Asmat Shaheen
Mukhtiar Zaman Afridi
Nafees Ahmad
Rashda Abassi
Nasir Ahmad
Sami Siraj

Abstract

Objective: To integrate the quantitatively existing evidences on nocturnal asthma
and their association with β2-adrenergic receptor (Arg16Gly and Glu27Gln)
polymorphism.
Methodology: The whole procedure for systematic review and meta-analysis
was conducted following PRISMA guidelines. The following databases Ovid,
PubMed, Wiley online library, Springer link and the Web of Knowledge were
searched for relevant articles. Random effect meta-analysis was conducted.
Heterogeneity was evaluated by I2 statistic. The funnel plots and the Eager tests
were used to assess the small study biases and potential publications.
Results: This systematic review and meta-analysis comprised a total of 9 studies.
The brief statement estimates suggested heterozygous Arg/Gly (OR =2.32;
95% CI =1.53-3.54; P value =<0.001), homozygous Gly (OR =4.78; 95% CI =2.60-
8.77, P-value =<0.001) and Gly allele (OR =1.71, 95% CI =1.14-2.56, P-value
=0.009) was significantly associated with nocturnal asthma. While Glu27Gln
polymorphism did not showed significant association with nocturnal asthma
both in genotype (OR =1.28; 95% CI =0.63-2.59; P-value =0.496) and allelic (OR
=1.65; 95% CI =0.64-4.27; P-value =0.301) analysis.
Conclusion: Heterozygous Arg/Gly, homozygous Gly/Gly and Gly Allele were
found to be significantly associated with nocturnal asthma.

Article Details

How to Cite
1.
Khan I, Ul Haq Z, Shaheen A, Afridi MZ, Ahmad N, Abassi R, Ahmad N, Siraj S. SYSTEMATIC REVIEW AND META-ANALYSIS OF ASSOCIATION OF β2-ADRENERGIC RECEPTOR GENE POLYMORPHISMS WITH NOCTURNAL ASTHMA. J Postgrad Med Inst [Internet]. 2017 Aug. 10 [cited 2022 Jul. 7];31(3). Available from: https://www.jpmi.org.pk/index.php/jpmi/article/view/2105
Section
Original Article
Author Biographies

Ihsanullah Khan, Institution Address: Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.

MPhil Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.

Zia Ul Haq, Institute of Public Health and Social Sciences, Khyber Medical University Peshawar, Pakistan

Associate Professor,

Institute of Public Health and Social Sciences, Khyber Medical University Peshawar, Pakistan

Asmat Shaheen, Kohat Institute of Medical Sciences, Kohat

Assistant Professor,Kohat Institute of Medical Sciences, Kohat

Mukhtiar Zaman Afridi, Department Pulmonology, Leady reading hospital Peshawar.

Professor and Medical Director LRH-Peshawar.

Nafees Ahmad, : Institute of Biomedical & Genetic Engineering, Islamabad, Pakistan

Principal Scientific Officer,: Institute of Biomedical & Genetic Engineering, Islamabad, Pakistan

Rashda Abassi, Institute of Biomedical & Genetic Engineering, Islamabad, Pakistan

Senior Scientist,: Institute of Biomedical & Genetic Engineering, Islamabad, Pakistan

Nasir Ahmad, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.

PhD Scholar,Pharmacology

Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.

Sami Siraj, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.

Assistant Professor,Pharmacology

Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.