Main Article Content
Objective: To represents the demographic profile, clinical characteristics, frequency of risk factors and distribution of lesions and findings on coronary angiogram in acute coronary syndrome (ACS) patients.
Methodology: This retrospective cross sectional study was conducted from January 2020 to December 2021 at the Department of Cardiology, Lady Reading Hospital, Peshawar. Clinical profile, risk factors and angiographic finding were collected from the history ans medical record of patients and entered on proforma. The study comprised of all patients presenting with ACS to tertiary care set up. Inclusion criteria was patients presenting with chest pain suggestive of angina presenting to the ER of the hospital
Results: Of the total 800 patients, 62.50 % were male. Mean age of the study population was 55.58±11.16. Majority had normal BMI. Overall, 33.75% of the patients were smoker. Hypertension was present in 48 % of the patients. Diabetes mellitus and dyslipidemia was observed in 38.8% and 31.2% respectively. Most common presenting complaint was chest pain. Myocardial infarction was observed in 33.25% of the patients. Angiographic distribution of lesion showed that 20.38% had SVCAD. About 30% had DVCAD and 27.50% had TVCAD. On the other hand, 22.25% patient had normal coronary vessel. PCI was performed in 350(43.75%) of the patients where CABG was recommended in 16.13%. Right dominance was observed in 705(88.12%) of the individuals.
Conclusion: Single vessel coronary artery disease is the most common finding and most common treatment option is PCI. Hypertension and smoking were the most common risk factors in patients presenting as ACS.
Work published in JPMI is licensed under a
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Murray CJL, Lopez AD, editors. The Global burden of disease : a comprehensive assessment of mortality and disability from diseases, injuries and risk factors in 1990 and projected to 2020. Geneva: World Health Organization; 1996. Available from URL: https://apps. who.int/iris/handle/10665/41864?-show=full
Asada Y, Yamashita A, Sato Y, Hatakeyama K. Pathophysiology of atherothrombosis: Mechanisms of thrombus formation on disrupted atherosclerotic plaques. Pathol Int. 2020;70(6):309– 22. DOI:10.1111/pin.12921
World Health Statistics 2008. Geneva: World Health Organization; 2008. Available from URL: https://apps.who.int/ iris/handle/10665/43890
American Heart Association / American Stroke Association statistical data on highlights of acute coronary syndrome, 2005.
Khan MA, Hashim MJ, Mustafa H, Baniyas MY, Al-Suwaidi SKBM, Al-Katheeri R, et al. Global epidemiology of ischemic heart disease: Results from the Global Burden of disease study. Cureus. 2020;12(7):e9349. DOI:10.7759/cureus.9349
Kulshrestha P, Gupta P. Study of the Effect of Urbanization on Coronary Heart Disease. Themat J Appl Sci. 2021;10(7):1-6.
Enas EA, Yusuf S, Mehta JL. Prevalence of coronary artery disease in Asian Indians. Am J Cardiol. 1992;70(9):945–9. DOI:10.1016/0002-9149(92)90744-j
Deedwania P, Singh V. Coronary artery disease in South Asians: evolving strategies for treatment and prevention. Indian Heart J. 2005;57(6):617-31.
Gupta R, Gupta VP. Meta-analysis of coronary heart disease prevalence in India. Indian Heart J. 1996;48(3):241- 5.
Deshmukh PP, Singh MM, Deshpande MA, Rajput AS. Clinical and angiographic profile of very young adults presenting with first acute myocardial infarction: Data from a tertiary care center in Central India. Indian Heart J. 2019;71(5):418–21. DOI:10.1016/j. ihj.2019.12.004
Gallucci G, Tartarone A, Lerose R, Lalinga AV, Capobianco AM. Cardiovascular risk of smoking and benefits of smoking cessation. J Thorac Dis. 2020;12(7):3866–76. DOI:10.21037/ jtd.2020.02.47.
Akanda MAK, Ali SY, Islam A, Rahman MM, Parveen A, Kabir MK, et al. Demographic profile, clinical presentation & angiographic findings in 637 patients with coronary heart disease. Faridpur Med Coll J. 1970;6(2):82–5. DOI:10.3329/fmcj.v6i2.9206
Kadam VK. Clinical profile and outcomes of patients presenting with acute coronary syndrome in a tertiary care hospital. MGM J Med Sci. 2019;6(3):113.
Abdelmonaem MM, Nour A, Reda A. Comparison Between Plaque Rupture and Plaque Erosion in the Setting of Acute Coronary Syndrome: Patient Characteristics and Procedural Outcomes. Iran Heart J. 2022;23(2):75– 86.
Khan KA, Khan MN, Kumar R, Shah JA, Kumar D, Qayyum D, et al. Clinical profile and angiographic pattern of coronary artery disease in young patients with Acute coronary syndrome. J Med Imaging Health Inform. 2021;11(12):3010–5. DOI:10.1166/ jmihi.2021.3889
Revaiah PC, Vemuri KS, Vijayvergiya R, Bahl A, Gupta A, Bootla D, et al. Epidemiological and clinical profile, management and outcomes of young patients (40 years) with acute coronary syndrome: A single tertiary care center study Indian Heart J. 202;73(3):295- 300.
Paudel N. Clinical Profile and Outcomes of Patients Undergoing Percutaneous Coronary Intervention: A 5 Year Experience. J Coll Med Sci-Nepal. 2021;17(4):308-15. DOI:10.3126/ jcmsn.v17i4.40838