EFFICACYAND SAFETY OF INTERFERON ALPHA 2 B PLUS RIBAVIRIN COMBINATION IN CHRONIC HEPATITIS C PATIENTS WITH PULMONARY TUBERCULOSIS

Main Article Content

Rukhsana Javed Farooqi
Javed Iqbal Farooqi

Abstract

Objective: To assess the efficacy of combination therapy of interferon alpha-2b plus Ribavirin in patients

of chronic hepatitis C and pulmonary TB

Material and Methods: This retrospective study comprised of personal series of patients in

Gastroenterology Unit, HMC Peshawar and Saidu Group of Teaching Hospitals Swat, from June 1999 to

December 2002. Records of chronic hepatitis C and pulmonary TB, were analyzed for base-line

parameters, response rates, and any adverse effects. Standard anti-TB was given uninterrupted along with

close monitoring of all the patients.

Results: This study was conducted on 22 males and 11 females (33 patients) with chronic hepatitis C and

pulmonary tuberculosis.

End-treatment response:

 

 

Sustained viral response:

 

 

 

Serum ALT levels remained normal and HCV-RNA PCR remained undetectable

 

at the end of 6 months follow-up period in 15 out of 22 male patients (68.18%), as compared to 8 out of

11 female patients (72.72%), (P > 0.05).

Conclusion: We conclude that Interferon plus Ribavirin combination therapy is an effective and safe

therapy in the treatment of chronic hepatitis C patients having pulmonary TB.

 

serum ALT levels became normal in 18 out of 22 male patients (81.81%), as

 

compared to 10 out of 11 female patients (90.90%), (P > 0.05). Serum HCV-RNA became negative in 17

out of 22 male patients (77.27%), as compared to 9 out of 11 female patients (81.81%), (P > 0.05).

Article Details

How to Cite
1.
Farooqi RJ, Farooqi JI. EFFICACYAND SAFETY OF INTERFERON ALPHA 2 B PLUS RIBAVIRIN COMBINATION IN CHRONIC HEPATITIS C PATIENTS WITH PULMONARY TUBERCULOSIS. J Postgrad Med Inst [Internet]. 2011 Jul. 25 [cited 2022 Dec. 9];19(2). Available from: https://www.jpmi.org.pk/index.php/jpmi/article/view/32
Section
Original Article

Most read articles by the same author(s)

1 2 > >>