Haemodynamic Effects of Captopril in Congestive Cardiac Failure Due to Rheumatic Heart Disease

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Muhammad Hafizullah
Waheed A. Sahibzada

Abstract

Rheumatic heart disease is a leading cause of congestive cardiac failure. Besides conventional therapy ACE Inbibitors have been found useful in patients with congestive cardiac failure. This study was conducted in 13 patients with CCF due to RHD to see the acute hemodynamic effects of an ACE inhibitor captopril, Captopril 25mg was orally administered and heamodynamic changes were recroded at fixed intervals. The pulmonary wedge pressure dropped by 21 % p <.001. Cardiac index improved by 8 % p <.01. Captopril has a beneficial effect in patients with CCF because of lowering of preload and afterload with little effect on cardiac output and heart rate.

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1.
Hafizullah M, Sahibzada WA. Haemodynamic Effects of Captopril in Congestive Cardiac Failure Due to Rheumatic Heart Disease. J Postgrad Med Inst [Internet]. 2011 Aug. 28 [cited 2022 Oct. 4];9(2). Available from: https://www.jpmi.org.pk/index.php/jpmi/article/view/499
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