CAUSATIVE FACTORS AND CLINICAL OUTCOME IN STEVEN JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS
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Published:
May 12, 2017
Keywords:
Steven Johnson syndrome, Toxic epidermal necrolysis, Anticonvulsants, Antibiotics, Clinical outcome
Main Article Content
Abstract
Objective: To identify the main factors causing Steven Johnson syndrome (SJS)
and toxic epidermal necrolysis (TEN) and their clinical outcome in the patients
in our local setup.
Methodology: This case series was conducted at Lady Reading Hospital, Peshawar.
A total of 54 consecutive patients who presented with Steven Johnson
syndrome and toxic epidermal necrolysis over a two year period (2013-2015)
were included in the study. Relevant information including bio-data, causative
agents, duration of hospital stay and outcome in terms of improvement or mortality
was collected. Analysis was done using SPSS version 20.
Results: The mean age of patients presenting with SJS/TEN was 25.9±17.4
years with a minimum age of 1 year and a maximum age of 65 years. Majority
of patients were between 18-45 years of age. The causes identified for triggering
SJS/TEN were anticonvulsants (38.9%), followed in equal frequency by
antibiotics and NSAIDS (27.8%) while 5.5% of cases were secondary to herpes
virus infection. Patients had a variable course with 83.3% of patients improving
with no sequel on follow-up and 16.7% succumbing to the disease.
Conclusion: Anticonvulsants, antibiotics and NSAIDS were the most frequently
responsible drugs for development of SJS & TEN. The Observed mortality rate
was 16.7%.
and toxic epidermal necrolysis (TEN) and their clinical outcome in the patients
in our local setup.
Methodology: This case series was conducted at Lady Reading Hospital, Peshawar.
A total of 54 consecutive patients who presented with Steven Johnson
syndrome and toxic epidermal necrolysis over a two year period (2013-2015)
were included in the study. Relevant information including bio-data, causative
agents, duration of hospital stay and outcome in terms of improvement or mortality
was collected. Analysis was done using SPSS version 20.
Results: The mean age of patients presenting with SJS/TEN was 25.9±17.4
years with a minimum age of 1 year and a maximum age of 65 years. Majority
of patients were between 18-45 years of age. The causes identified for triggering
SJS/TEN were anticonvulsants (38.9%), followed in equal frequency by
antibiotics and NSAIDS (27.8%) while 5.5% of cases were secondary to herpes
virus infection. Patients had a variable course with 83.3% of patients improving
with no sequel on follow-up and 16.7% succumbing to the disease.
Conclusion: Anticonvulsants, antibiotics and NSAIDS were the most frequently
responsible drugs for development of SJS & TEN. The Observed mortality rate
was 16.7%.
Article Details
How to Cite
1.
Paracha MM, Noor SM, Khan HA. CAUSATIVE FACTORS AND CLINICAL OUTCOME IN STEVEN JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS. J Postgrad Med Inst [Internet]. 2017 May 12 [cited 2024 Apr. 20];31(2). Available from: https://www.jpmi.org.pk/index.php/jpmi/article/view/2072
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