COMPARISON OF THE EFFICACY OF TAZAROTENE 0.1% GEL WITH ADAPALENE 0.1% GEL IN THE TREATMENT OF FACIAL ACNE VULGARIS
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Abstract
Objective: To compare the efficacy of tazarotene 0.1% gel with adapalene 0.1% gel in the treatment of facial acne vulgaris.
Methodology: This randomized control trial (RCT) was carried out from February to August 2019 in the Department of Dermatology, Lady Reading Hospital, Peshawar. A total of 106 Acne Vulgaris patients were enrolled in the study using non-probability consecutive sampling. A detailed history followed by through clinical examination was conducted for all patients. All patients were randomly allocated in two groups (Group A and Group B) by lottery method. In group A, patients were treated by topical tazarotene gel (0.1%) while the other group had topical adapalene gel (0.1%). Data was analyzed by SPSS version 22, descriptive and analytical statistics were applied where needed.
Results: In present study, age of patients in Group A and B were 28±10.77 years and 30±11.12 years respectively. The male to female ratio in both groups was 1:1.5. In group A, topical tazarotene gel (0.1%) was effective in 72% of the cases whereas topical adapalene gel (0.1%) recorded effectiveness in 62% of cases (p-value=0.3017).
Conclusion: We concluded that Tazarotene 0.1% gel is a more effective treatment option for facial acne vulgaris when compared with Adapalene 0.1% gel.
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References
Lynn DD, Umari T, Dunnick CA, Del¬lavalle RP. The epidemiology of acne vulgaris in late adolescence. Adolesc Health Med Ther. 2016; 7:13-25.
Tan JK, Bhate K. A global perspective on the epidemiology of acne. B J Der¬matol. 2015; 172:3-12.
Gencler B, Keseroglu O, Kartal SP, Gonul M. Pediatric Acne. In: Selda PK and Müzeyyen G (eds) Acne and Ac¬neiform Eruptions. IntechOpen. 2017, pp.41-49.
Zouboulis CC. Acne as a chronic sys¬temic disease. Clin Dermatol. 2014; 32(3):389-96.
Chuah SY, Goh CL. The impact of post-acne scars on the quality of life among young adults in Singapore. J Cut Anesth Surg. 2015; 8(3):153-58.
Niemeier V, Kupfer J, Gieler U. Acne vulgaris–psychosomatic aspects. JDDG. 2006; 4(12):1027-36.
Nast A, Dréno B, Bettoli V, Bukvic Mokos Z, Degitz K, Dressler C, et.al. European evidence-based (S3) guide¬line for the treatment of acne–update 2016–short version. J Eur Acad Der¬matol Venereol. 2016; 30(8):1261-8.
Pena S, Hill D, Feldman SR. Use of topical retinoids by dermatologists and non-dermatologists in the man-agement of acne vulgaris. J Am Acad Dermatol. 2016; 74(6):1252-54.
Silva EL, Carneiro G, de Araújo LA, de Jesus M, Trindade V, Yoshida MI et al. Solid Lipid Nanoparticles Loaded with Retinoic Acid and Lauric Acid as an Alternative for Topical Treatment of Acne Vulgaris. J Nanosci Nanotech. 2015; 15(1):792-9.
Higgins S, Wesley NO. Topical Reti¬noids and Cosmeceuticals: Where Is the Scientific Evidence to Recommend Products to Patients? Curr Derm Rep. 2015; 4(2):56-62.
Tan X, Davis SA, Balkrishnan R, Krow¬chuk DP, Feldman SR. Factors associ¬ated with topical retinoid prescriptions for acne. J Dermatolog Treat. 2014; 25(2):110-4.
Khurshid K, Pal SS. Comparison of ef¬ficacy and tolerability of topical 0.1% adapalene gel with 0.05% isotretinoin gel in the treatment of acne vulgar¬is. J Pak Assoc Dermatol. 2012; 22(3):240-247.
Swaroop MR. A Comparative Study of Efficacy of once Daily 0.1% Taza¬rotene and Adapalene Gel for the Treatment of Facial Acne Vulgaris. Ind J Clin Exp Dermatol. 2015; 1(1):4-8.
Rahman MH, Sikder MS, Khondker L. Efficacy and tolerability of 0.1% tazarotene cream and 0.05% tretinoin cream in the treatment of acne vul¬garis. Bang Sheikh Mujib Med Univ J. 2016; 8(1):24-9.
Tanghetti E, Dhawan S, Green L, Del Rosso J, Draelos Z, Leyden J et al. Randomized comparison of the safe¬ty and efficacy of tazarotene 0.1% cream and adapalene 0.3% gel in the treatment of patients with at least moderate facial acne vulgaris. J Drugs Dermatol. 2010; 9(5):549-58.
Webster GF, Guenther L, Poulin YP, Solomon BA, Loven K, Lee J. A mul¬ticenter, double blind, randomized comparison study of the efficacy and tolerability of once daily tazarotene 0.1% gel and adapalene 0.1% gel for the treatment of facial acne vulgaris Cutis. 2002; 69(2 l):4-11.