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Objective: To evaluate the effect of Memantine on cognitive functions andlevel of dependency of patients with Alzheimer dementia.
Methodology: This descriptive study was conducted at department of Psychiatry,Lady Reading Hospital Peshawar from February to June 2012. Sampleconsisted of 55 patients; both male and female and were included throughconsecutive sampling. Patients were assessed at baseline and at three monthsfollow up for Cognitive functions and level of dependency with the use of MiniMental State Examination (MMSE) and Clifton Assessment Procedures for theElderly (CAPE) as psychometric tools.
Results: Fifty five patients with Dementia were included in the study. Fortythree patients completed their follow up visits. Mean score of the patientswho completed follow up on MMSE at baseline was 17.47+6.04, while meandependency grade of CAPE at baseline was 3.67+1.44. Mean score on MMSEat follow up was 19.67+ 5.88 while mean dependency grade of CAPE was2.67+1.39. Significant difference was found between the scores on base lineand follow up with the p=0.00.
Conclusion: We concluded from our study that Memantine has useful rolein the improvement of the cognitive functions and behavioral dependency ofthe demented patients as there were significant improvements seen in bothcognitive functions and level of dependency of the patients with Alzheimerdementia after 3 months follow up assessment.
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