Comparative Efficacy and tolerability of Lasoride and Spiromide in congestive Cardiac Failure
Main Article Content
Abstract
Diuretics play primary role in fluid over loaded patients with CCF. Combination of potassium sparing agents with loop diuretics enhance the diuretic effect, conserve potassium and reduce the number of tablet. This study was carried out to see the efficacy safety and tolerability of lasoride against spiromide. This was a short term, randomised signle blind study. Patients were assessed for clinical hemodynamic and biochemical changes. Patients were well matched regarding age, sex, weight, hemodynamic and biochemical status. both the drugs improved clinical signs and symptoms without much effect on biochemical status. Gastrointestinal side effects were more common in spiromide group (42%) Vs 5%) and Gynaecomastic was more frequent in spiromide group (25% Vs 2.5%) in lasoride (p<0.05). Both lasoride and spiromide were effective and safe; lasoride was better in tolerability.
Article Details
How to Cite
1.
Hafizullah M, Bangash K, Abbas F. Comparative Efficacy and tolerability of Lasoride and Spiromide in congestive Cardiac Failure. J Postgrad Med Inst [Internet]. 2011 Sep. 15 [cited 2024 Dec. 10];14(1). Available from: https://www.jpmi.org.pk/index.php/jpmi/article/view/680
Issue
Section
Original Article
Work published in JPMI is licensed under a
Creative Commons Attribution-NonCommercial 2.0 Generic License.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.